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Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic -cell dysfunction and death in vitro

Any references to metabolic, endocrine, or appetite-related pathways are provided strictly for scientific context within laboratory research and do not imply therapeutic, diagnostic, or clinical use

After oral treatment with betanin, they found that followed by a significant increase of glycolytic enzyme (glucokinase and pyruvate kinase), glucose6phosphate dehydrogenase, and decrease in the activity of gluconeogenic enzymes (glucose6phosphatase and fructose1,6bisphosphatase), the levels of plasma glucose, insulin, glycosylated hemoglobin (HbA1c), and hemoglobin (Hb) were restored in diabetic rat

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